Santo Stefano di Sessanio is a comune and hill town in the province of L'Aquila in the Abruzzo region of southern Italy. Located in the Gran …Santo Stefano di Sessanio is a comune and hill town in the province of L'Aquila in the Abruzzo region of southern Italy. Located in the Gran Sasso e Monti della Laga National Park, in the highest region of the Apennines, this medieval hill town sits adjacent to the high plain of Campo Imperatore. It is one of I Borghi più belli d'Italia.