Previous attempted therapies for heart failure have shown improvements to heart function on the order of 5-10%. cBIN1 gene therapy improved function by 30%. "It's night and day," Shaw adds.

To try and increase cBIN1 levels in cases of heart failure, the scientists turned to a harmless virus commonly used in gene therapy to deliver an extra copy of the cBIN1 gene to heart cells. They ...

To try and increase cBIN1 levels in cases of heart failure, the scientists turned to a harmless virus commonly used in gene therapy to deliver an extra copy of the cBIN1 gene to heart cells.

Their study showed that the adeno-associated virus 9 (AAV9)-packaged cardiac bridging integrator 1 (cBIN1) gene therapy increased the amount of blood the heart can pump and dramatically improved ...

TUESDAY, Dec. 10, 2024 (HealthDay News) -- Failing hearts nearly returned to full function in laboratory pigs after they received an experimental gene therapy. New research shows the gene therapy didn ...

At the University of Utah, scientists used a new gene therapy that was shown to reverse ... have low levels of cardiac bridging integrator 1 (cBIN1), a critical heart protein.

To try and increase cBIN1 levels in cases of heart failure, the scientists turned to a harmless virus commonly used in gene therapy to deliver an extra copy of the cBIN1 gene to heart cells.

For the gene therapy, researchers placed an extra copy of the cBIN1 gene into a hollowed-out virus, then injected the virus into the four pigs. The virus moved through the bloodstream to the heart ...

Cell boundaries, labeled in magenta, are more organized after gene therapy, and the level of cBIN1 protein (green) is higher. "Even though the animals are still facing stress on the heart to ...