NFL season appears over for Christian McCaffrey. Isaac Guerendo, now set to be the 49ers' starting running back, has shared his thoughts on stepping up.

McCaffrey's old backfield mate discussed the trials and tribulations of a season-ending injury on his podcast.

The 49ers — who were already without Trent Williams, Nick Bosa and Deommodore Lenoir — saw Christian ... a PCL injury, according to head coach Kyle Shanahan. On Monday, the 49ers put McCaffrey ...

The 28-year-old took to social media on Wednesday to share a heartfelt message for 49ers fans after his injury-plagued ...

49ers coach Chris Foerster believes Isaac Guerendo is ready for a bigger role in Week 14. When Christian McCaffrey landed on ...

Despite retaining the core that drove them to the Super Bowl, injuries to key personnel like Christian McCaffrey ... a posterior cruciate ligament (PCL) injury, ending his stop-start 2024 season. In a ...

The San Francisco 49ers' exceedingly deep backfield thinned out rapidly when running backs Christian McCaffrey and Jordan ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...

Both Christian McCaffrey and Trevor Lawrence were ruled ... and led to a three-game suspension for Texans linebacker Azeez Al-Shaair, McCaffrey's posterior cruciate ligament (PCL) injury also sent ...

The San Francisco 49ers are banking on rookie running Isaac Guerendo to fill the shoes left by a former Offensive Player of ...