The Los Angeles Rams and San Francisco 49ers aren't in a "must-win" situation, yet the loser of this "Thursday Night Football ...

Since training camp, the 49ers season hasn't gone as planned amid injuries to star players and on-field struggles.

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

The beat-up San Francisco 49ers hope to keep their faint playoff hopes alive when they host the struggling Chicago Bears in ...

Also out is 49ers RB Christian McCaffrey, one of the NFL’s most dynamic players. He’s battled injuries all season and is now ...

Superstar edge rusher Nick Bosa is officially ruled out for Sunday's contest against the Bears, according to ESPN's Adam ...