Since training camp, the 49ers season hasn't gone as planned amid injuries to star players and on-field struggles.

Blink and you might miss it. That’s reality of life in the NFL when it comes to Super Bowl windows. Sure, the elite tier of ...

San Francisco 49ers running back Christian McCaffrey was the near-consensus No. 1 pick in fantasy football drafts. However, ...

San Francisco 49ers running back Christian McCaffrey (knee) suffered a PCL injury just four games into his return from the ...

San Francisco 49ers head coach Kyle Shanahan addressed reporters during a Monday conference call, a day after the team's dominant 38-13 victory over the Chicago Bears. He shared several injury updates ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

NFL Week 15 odds, picks, predictions, TV channel, streaming for Thursday Night Football game between Los Angeles Rams and San ...

San Francisco 49ers rookie running back Isaac Guerendo sustained a foot injury and is questionable to return in Sunday's ...

The 49ers have lost both of their top running backs to injuries. So how who will replace Christian McCaffrey and Jordan Mason ...

San Francisco 49ers running back Christian McCaffrey was placed on injured reserve and is likely out for the season after suffering a PCL injury in Week 13 agai ...

San Francisco 49ers head coach Kyle Shanahan and quarterback Brock Purdy spoke with reporters after Friday's practice as the ...

Superstar edge rusher Nick Bosa is officially ruled out for Sunday's contest against the Bears, according to ESPN's Adam ...