p21 - Wikipedia
p21 is a potent cyclin-dependent kinase inhibitor (CKI). The p21 (CIP1/WAF1) protein binds to and inhibits the activity of cyclin-CDK2, -CDK1, and -CDK4 /6 complexes, and thus functions as a regulator of cell cycle progression at G 1 and S phase.
Protein discovery could add 7 years to human lifespan -- and …
Aug 12, 2024 · The study, published in Cell Metabolism, focuses on cells that highly express a protein called p21. These “p21-high” cells accumulate in various tissues as we age and appear to contribute to age-related decline.
Research highlights p21's multifunctional role beyond cell cycle …
Aug 28, 2024 · Results show that p21-tdT + HSCs display increased self-renewal and reconstitution abilities. Zbtb18, upregulated in p21-tdT + HSCs, is crucial for their repopulation capability. p21 interacts...
Cellular senescence, p21, and the path to fibrosis
Sep 30, 2024 · A recent study shows that p21 (CDKN1A) regulates expression of extracellular matrix components by senescent cells, promoting tissue fibrosis and immune cell infiltration.
What is the Effect of P21 in Cellular Function? - News-Medical.net
Feb 3, 2020 · Cyclin-dependent kinase inhibitor 1, also known as CDK-interacting protein 1, or more simply as p21, is a cell cycle inhibitor that promotes both CDK/cyclin inhibition as well as cell cycle...
P21 news and latest updates - Medical Xpress
All the latest news about p21 from Medical Xpress. Topics. Conditions. Week's top; Latest news; Unread news; ... p21; News tagged with p21. Date. 6 hours 12 hours 1 day 3 days all. Rank. Last day ...
Inhibition of p21 activates Akt kinase to trigger ROS-induced
Dec 15, 2022 · Owing to its ability to induce cellular senescence, inhibit PCNA, and arrest cell division cycle by negatively regulating CDKs as well as being a primary target of p53, p21 is traditionally...
P21 news and latest updates - Phys.org
p21 / WAF1 also known as cyclin-dependent kinase inhibitor 1 or CDK-interacting protein 1 is a protein that in humans is encoded by the CDKN1A gene located on chromosome 6 (6p21.2).
p21: One protein to rule cell fate | Science Translational Medicine
Hsu and colleagues elegantly demonstrated in vitro that initial expression of p21 after chemotherapy exposure controls downstream cell fate after DNA damage induced by 1-day treatment with doxorubicin.
p21 produces a bioactive secretome that places stressed cells …
Our study illuminates that immediate-early cell-autonomous reactions to cellular stress are coordinated with cell non-autonomous responses through p21-mediated changes in the Rb-dependent transcriptional landscape to establish a biological timer mechanism for …